The Permian Basin in West Texas, a major energy-producing region in the USA, consists of ancient marine rocks underlain by water-soluble rocks and multiple hydrocarbon-rich formations. Densely populated oil and gas-producing facilities have impacted the stability of the solid Earth, inducing long-lasting surface subsidence and uplift and the formation of sinkholes and fissures. The ground instability and the associated geohazards threaten the safe operation of key infrastructure such as roads, hydrocarbon facilities, pipelines, and water management facilities. Using interferometric synthetic aperture radar (InSAR) images, we have mapped the temporal behaviors of the geohazards. The time-lapse InSAR measurements are compared to collected human activity data to reveal and correlate the causality of the geohazards with the type of anthropogenic perturbations (e.g., wastewater injection, CO2 flooding, abandoned wells, salt dissolution, mining, etc.). We have quantified the impacts of human activities on the stability of the solid Earth through numerical poroelastic modeling, which simulates the induced stress/pressure distribution in the strata and the resulting surface subsidence/uplift. By identifying the triggering factor(s) behind human-induced geohazards that have already occurred, our in-depth study provides insights for the mitigation of environmental impacts and assists the decision-making of public authorities and private oil and gas companies as they strive to minimize negative environmental impact and financial risk while supporting the sustainable growth of the petroleum industry.